“Glutamate Blockers”? Natural Ways/Supplements To Improve Glutamate Levels
You may want to read first this article to better understand the functions of glutamate and how glutamate becomes toxic to the brain and promotes inflammation and autoimmunity. I know many are looking for “glutamate blockers”. Rather than blocking glutamate, you actually need to improve its levels/ its pathways. How To Improve Glutamate Levels/Glutamate Pathways PPAR-γ Activators Aminoacids : Taurine and NAC Probiotics Vitamins and Minerals : Vitamins: Bs, C, E, D, Magnesium, Lithium Orotate Lifestyle Changes/Therapies: Diet, Exercise, Sleep, Acupuncture How To Improve Glutamate Levels *GE =glutamate excitotoxicity Glutamate is an essential (and the main excitatory) neurotransmitter in the brain. However, glutamate can become toxic- a process called glutamate excitotoxicity (GE)- in a few circumstances:if there is excess glutamate in the brain or the glutamate receptors are overstimulated. EC can also develop when the glutamate levels are normal but the glutamate receptors are over sensitive or when the glutamate pathways are impaired (ie problems with the enzymes, transporters, etc). GE plays a key role in neurodegeneration. Thus, researchers are looking into drugs and therapies focused on improving glutamate pathways to treat degenerative brain diseases. Technical: excessive activation of glutamate receptors by excitatory amino acids leads to a number of negative effects ie impairment of cellular calcium homeostasis, generation of free radicals, activation of the mitochondrial permeability transition and secondary GE [1]. Quick note: GE is also associated with...
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