Month: May 2018

How To Treat Orexin Deficiency Naturally, Including Best Supplements For Fatigue and Sleepiness

Posted by | May 28, 2018 | , |

There are quite a few effective ways to treat orexin deficiency naturally. You may want to read first this article about orexins: The Link Between Orexin Deficiency And Fatigue, Muscle Weakness, Neurodegeneration and MS Let’s start with diet and other lifestyle changes and therapies, then you will learn about vitamins for tiredness and lack of energy and some of the best energy supplements for chronic fatigue- including MS chronic fatigue.  Diet  Vagus Nerve Stimulation Light Therapy Exercise Cold Therapy Supplements For Fatigue and Sleepiness Associated With Orexin Deficiency   1.Diet Orexin neurons are activated by fasting and low sugar levels [1]. This means that low carb diets including ketogenic diet, as well as fasting will stimulate orexins. Technical: the high concentrations of glucose and leptin tend to hyperpolarize orexinergic neurons, while low concentrations of glucose and ghrelin depolarize them [2].  Allowing your body to use alternate sources of energy for cells- ie pyruvate or lactate instead of glucose, does activate orexins. These alternate sources seem to stop glucose from blocking orexin neurons [3].You can increase lactate levels with fermented foods (pickled foods, kombucha, kefir, etc), olives and exercise (particularly high intensity exercise and resistance training). Orexins are activated by high protein diets [4]. The top three aminoacids that activate orexins are glycine, aspartate and cysteine [5]. BCAA (Branched Chain Amino Acids) leucine, isoleucine, and valine also seem helpful, as they can restore orexin levels...

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About Orexins. The Link Between Orexin Deficiency And Fatigue, Muscle Weakness, Neurodegeneration and More

Posted by | May 21, 2018 | , |

  If you experience chronic, extreme fatigue, you need to know about orexins. Orexins are like norepi or dopamine -on steroids. They have powerful “anti-fatigue” effects in addition to controlling a wide range of physiological activities. 1.About Orexins and Symptoms of Orexin Deficiency 2.Orexins In The Brain 3.Orexin In The Gut/Role In Metabolism 4.Orexins and Autonomic Nervous System (ANS) 5.Orexin And Pain 6.Orexin And Hormones 7.Orexins And Motor Activity 8.Orexin System in MS, Parkinson’s and Other Brain Conditions 9.Could Orexin Deficiency Be The Hidden Cause of MS ? How To Treat Orexin Deficiency Naturally- In This Article 1.About Orexins and Symptoms of Orexin Deficiency I wrote about norepinephrine, an important neurotransmitter/ hormone involved in “fight or flight” reaction that keeps you awake and alert, and how fatigue is a key symptom of norepi deficiency. Dopamine, serotonin and acetylcholine deficiencies can also lead to fatigue.Technical: Orexin neurons have a stimulating (excitatory) effect on every wakefulness promoting neuronal group tested by researchers so far, according to a 2015 study [1].   Here is a good example to remember the role of orexins in wakefulness: narcolepsy, a condition characterized by excessive daytime sleepiness, episodes of falling asleep during the daytime and sudden loss of muscle tone is caused by loss of orexins (90% of orexin neurons are lost in narcolepsy) [2] Do you have some of the following symptoms ? Extreme fatigue with day time...

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“Glutamate Blockers”? Natural Ways/Supplements To Improve Glutamate Levels

Posted by | May 16, 2018 | , |

  You may want to read first this article to better understand the functions of glutamate and how glutamate becomes toxic to the brain and promotes inflammation and autoimmunity. I know many are looking for “glutamate blockers”. Rather than blocking glutamate, you actually need to improve its levels/ its pathways. How To Improve Glutamate Levels/Glutamate Pathways  PPAR-γ Activators  Aminoacids : Taurine and NAC Probiotics Vitamins and Minerals : Vitamins: Bs, C, E, D, Magnesium, Lithium Orotate Lifestyle Changes/Therapies: Diet, Exercise, Sleep, Acupuncture   How To Improve Glutamate Levels *GE =glutamate excitotoxicity Glutamate is an essential (and the main excitatory) neurotransmitter in the brain. However, glutamate can become toxic- a process called glutamate excitotoxicity (GE)- in a few circumstances:if there is excess glutamate in the brain or the glutamate receptors are overstimulated. EC can also develop when the glutamate levels are normal but the glutamate receptors are over sensitive or when the glutamate pathways are impaired (ie problems with the enzymes, transporters, etc). GE plays a key role in neurodegeneration. Thus, researchers are looking into drugs and therapies focused on improving glutamate pathways to treat degenerative brain diseases. Technical: excessive activation of glutamate receptors by excitatory amino acids leads to a number of negative effects ie impairment of cellular calcium homeostasis, generation of free radicals, activation of the mitochondrial permeability transition and secondary GE [1]. Quick note: GE is also associated with...

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Neurotransmitters. Glutamate And MS- Is There A Connection ?

Posted by | May 13, 2018 | , |

Glutamate is a very important aminoacid for your health. It is found in abundance in the body, especially in the brain, gut and muscles. It is also a key neurotransmitter in the brain and gut. Healthy levels of glutamate are needed for optimal health. The problems occur when glutamate levels become too high- as it happens in MS and many other conditions. Glutamate In The Brain Glutamate In The Gut Glutamate In The Muscles Glutamate Effects On Oxidative Stress, Inflammation and Immune System Glutamate And MS Triggers/Factors That Increase Glutamate Levels/Disturb Glutamate Pathways Natural Ways/Supplements  To Improve Glutamate Levels- in THIS article    1.Glutamate In The Brain Glutamate is the main excitatory neurotransmitter in the brain and spinal cord. It is made in the brain from glucose. The aminoacido glutamine is also a precursor of glutamate. Let s look at Glutamine –>Glutamate–>  GABA conversion: Glutamine → Glutamate  →  GABA                                ↑                         ↓               Citric Acid Cycle ←    Succinate semialdehyde (SA)   High amounts of glutamate are found in the breast milk because it is essential for brain development. In healthy amounts, glutamate has important roles — it facilitates the communication between different brain cells- neurons, astrocytes, oligodendrocytes (myelin producing cells) and microglia (which connect the...

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What Does Taurine Do? Taurine Benefits

Posted by | May 11, 2018 | , , |

Let’s look at what does taurine do, sources and its benefits. About Taurine Taurine Benefits For The Brain Taurine Fights Inflammation, Is An Antioxidant, Improves Mitochondrial Function and Modulates The Immune System Taurine Influences Gene Expression, Improves Fertility and Promotes Longevity Taurine Benefits For The  Eyes, Ears and Mouth Health Taurine Benefits  For Diabetes (And Its Complications), Obesity and Metabolic Syndrome Taurine Benefits  For Digestion Taurine Benefits For Muscle Health Is Taurine Bad For You? Taurine Sources. Plus Why I Recommend It On and Off 1.About Taurine What does taurine do? A lot, as you will see in this article. In my opinion, taurine is underappreciated and underused.  Taurine is a sulfur containing aminoacid. Unlike other aminoacids that are incorporated into proteins, taurine is floating freely in the fluid within cells. It is found in abundance in the body, particularly the brain/ spinal cord, heart, retina, liver and muscles as well in the human breast milk. Taurine is also major constituent of bile and accounts for approximately 0.1% of total human body weight [1],[2],[3],[4]. Taurine is formed from amino acids methionine and cysteine and can also be synthesized in the liver and brain [5]. When taken from food, it is absorbed in the small intestine, transported to the liver than released in the bloodstream. The blood carries this amino acid to various organs. Although the body has its own mechanisms to prevent...

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