Month: November 2017

November 2017 NEWS -Including MS Remyelination Drug MD1003

Posted by | Nov 30, 2017 | , |

Biotin-as a  MS remyelination drug ?  Yes, biotin is the star in the news this month. Not in regular small doses, but high dose biotin.  High doses of biotin (a B vitamin)  can improve the myelination process and symptoms clinical in patients with multiple sclerosis, according to this new study [1] High doses biotin (MD1003 or Cerenday) had been researched  in the past (including a randomized, double-blind, placebo-controlled study) and showed significant improvement in signs and symptoms of PPMS and SMS (i.e.  improvements in walking, visual acuity and disability scale) Mechanism of actions: high dose biotin works by increasing the energy production in demyelinated axons and/or improving the synthesis of myelin in oligodendrocytes (the myelin producing cells). Be aware that high doses biotin can influence the thyroid tests. In animal studies ketogenic diet may cause biotin deficiency in biotin deficient animals. Therefore, biotin supplementation may be necessary if you follow a keto diet[2]. The brain gut connection Another study supporting the important role of gut microbiome in brain health. Unhealthy gut microbiota alters the blood brain barrier (BBB), affecting the brain health and influencing the progression of MS [3].   Potential new therapy targeting fibrinogen (a protein involved in blood clotting) . Based on this research, when the blood barrier is impaired (as it happens in MS), the fibrinogen from blood leaks into the brain and blocks myelination [4]....

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How to Improve Histamine Levels -Including Details About MS Remyelination Drug Clemastine

Posted by | Nov 17, 2017 | |

 Clemastine had been promoted as ms remyelination drug in the news just a month ago, read the details here. Is Clemastine for MS the best option among conventional drugs?     Why I wrote  this article : Optimal levels of histamine are essential for brain health in general, and managing MS in particular. MS has been linked with histamine excess. Antihistamine drug Clemastine may work as  a ms remyelination drug, according to recent studies. Be aware that this is just an example. Other  drugs that influence histamine receptors H1, H2, H3, H4 can be very helpful for MS. (will cover both pros and cons, my favorite ones and some research of these drugs for treating MS). To better understand the role of histamine and its receptors, read this article first. Another group of drugs – mast cell stabilizers- these drugs prevent the release of histamine from mast cells, thus used successfully in allergic conditions. Did you know research suggest that mast cell stabilizers could be the next generation of drugs for MS and other neurological conditions ? Yes, they can be that powerful. In these articles- here and here, I  reviewed of natural supplements that improve histamine levels and their importance  to treat MS. Not everything comes in a pill- there are other ways to optimize histamine levels,too.   Wondering why there is so little awareness about the role...

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Histamine and MS -Is There a Connection?

Posted by | Nov 15, 2017 | |

  What comes to your mind when you think of histamine? I bet you think about runny nose, itchy skin or other symptoms of allergies. While histamine plays a key role in allergic and inflammatory reactions, it is also very important for your brain and your entire body.     I.Histamine-Introduction II.Histamine Receptors III. The Link Between Histamine, Allergies (H1Rs)  and MS IV. Physiological Effects of Histamine (Allergies, Inflammation, Gastric Acid Secretion, Regulation of the Immune Response, Its Role in The Nervous System, Histamine & Hormones and Metabolism, Histamine & Stress)  Do You Want To Know How to Improve Histamine Levels Naturally With Diet, Supplements and More? – Read Here : Part I and Part II   I.Histamine-Introduction Histamine is an important  neurotransmitter and a signaling molecule in the gut, the skin, and the immune system. It formed from the amino acid histidine. It is found in almost all bodily tissues secreted by various cells (i.e mast cells, basophils, histamine producing neurons, gastric enterochromaffin-like cells,  histaminergic neurons, platelets, dendritic cells, T cells and some microbes). Histamine producing neurons are located in the hypothalamus and send their axons all over the central nervous system. They are active only when you are awake, as they promote arousal, wakefulness and attention [1].   II.Histamine Receptors Histamine receptors are proteins found in various parts of the body, and there are four of them : H1, H2,...

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